Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | GFER | P55789 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | CHKA | P35790 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10766576 | 0.80 | GAA (0.46) | MAPTALDH1A1LMNAGFERGAA | |
| SCHEMBL3439981 | 0.79 | CHKA (0.61) | MAPTALDH1A1LMNAGFERGAA | |
| SCHEMBL8564297 | 0.74 | SLC2A1 (0.42) | MAPTALDH1A1GAAMAPK1USP2 | |
| SCHEMBL7956152 | 0.68 | ACACB (0.52) | — | |
| SCHEMBL27930045 | 0.67 | MAPT (0.53) | MAPTGFERGAAKDM4EHTT | |
| Hydrochloric Acid SCHEMBL8634754 | 0.67 | GSK3B (0.45) | MAPTALDH1A1LMNAGFERGAA | |
| SCHEMBL23347931 | 0.67 | MAPT (0.77) | MAPTALDH1A1LMNAGFERGAA | |
| SCHEMBL6151120 | 0.67 | MAPT (0.77) | MAPTALDH1A1LMNAGFERGAA | |
| SCHEMBL28112415 | 0.67 | CHKA (0.80) | MAPTLMNAGAAKDM4EHTT | |
| SCHEMBL7043679 | 0.67 | MAPT (0.77) | MAPTALDH1A1LMNAGFERGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |