Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956169 | 0.84 | SLC2A1 (0.51) | SLC2A1SMN1; SMN2POLBHPGDMAPT | |
| SCHEMBL8565666 | 0.74 | MAPT (0.40) | SMN1; SMN2POLBMAPTALDH1A1GAA | |
| SCHEMBL15448546 | 0.71 | HDAC3 (0.61) | SMN1; SMN2TP53 | |
| SCHEMBL1423877 | 0.70 | SMN1; SMN2 (0.67) | SMN1; SMN2POLBHPGDALDH1A1GAA | |
| SCHEMBL25753493 | 0.70 | HDAC6 (0.63) | SMN1; SMN2HPGDMAPTALDH1A1GAA | |
| SCHEMBL7961490 | 0.70 | MAPT (0.54) | SLC2A1SMN1; SMN2MAPTDRD2AURKA | |
| SCHEMBL13701825 | 0.69 | MAPT (0.64) | SMN1; SMN2POLBHPGDMAPTALDH1A1 | |
| SCHEMBL8635363 | 0.65 | SLC2A1 (0.45) | SLC2A1SMN1; SMN2MAPTGAATP53 | |
| SCHEMBL17865779 | 0.65 | LMNA (0.58) | SMN1; SMN2POLBMAPT | |
| SCHEMBL7956272 | 0.65 | NPC1 (0.69) | SMN1; SMN2MAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |