Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 3/20 | 0.48 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL8559611 | 0.99 | GAA (0.49) | GAASMN1; SMN2CSF1RXDHSLC22A12 | |
| Water SCHEMBL8559615 | 0.99 | GAA (0.49) | GAASMN1; SMN2CSF1RXDHSLC22A12 | |
| SCHEMBL8564146 | 0.85 | CSF1R (0.50) | GAASMN1; SMN2CSF1RNPC1NPSR1 | |
| SCHEMBL8561203 | 0.77 | GAA (0.49) | GAASMN1; SMN2CSF1RAKR1C3AKR1C2 | |
| SCHEMBL8558688 | 0.77 | PDE4B (0.60) | GAASMN1; SMN2CSF1RALDH1A1NPC1 | |
| SCHEMBL8563378 | 0.76 | PDE4B (0.59) | GAASMN1; SMN2CSF1RALDH1A1NPC1 | |
| SCHEMBL8565303 | 0.76 | CSF1R (0.62) | CSF1RPDE4BEGFRERBB2 | |
| SCHEMBL8558823 | 0.76 | PDE4B (0.59) | GAASMN1; SMN2ALDH1A1NPC1HTT | |
| SCHEMBL9542093 | 0.76 | PDE4B (0.47) | GAASMN1; SMN2ALDH1A1NPC1HTT | |
| SCHEMBL8559490 | 0.76 | CSF1R (0.48) | CSF1RPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |
| WO-1993013097-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |