SCHEMBL8566620

SCHEMBL8566620

FC(F)c1ncc(C(NCc2ccccc2)C2CC2)c(Cl)n1

nearest known ligand 0.38

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 1/20 0.37
CTSS P25774 1/20 0.36
HDAC6 Q9UBN7 1/20 0.34
IDO1 P14902 1/20 0.32
PDCD1 Q15116 1/20 0.32
CD274 Q9NZQ7 1/20 0.32
ATM Q13315 1/20 0.32
ACHE P22303 1/20 0.31
AKT1 P31749 2/20 0.31
TACR1 P25103 2/20 0.31
SIGMAR1 Q99720 1/20 0.31
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8558953 0.71
SCHEMBL8470848 0.69 CYP3A4 (0.37) CTSSPDCD1CD274ACHEAKT1
SCHEMBL17605059 0.64 SIGMAR1 (0.52) IDO1ACHETACR1SIGMAR1POLB
Hydrochloric Acid SCHEMBL7624465 0.63 SIGMAR1 (0.43) IDO1ACHESIGMAR1POLB
SCHEMBL6803422 0.62 CTSS (0.52) CTSS
SCHEMBL17605050 0.61 SIGMAR1 (0.53) IDO1TACR1SIGMAR1POLB
SCHEMBL17605151 0.61 SIGMAR1 (0.53) IDO1TACR1SIGMAR1POLB
SCHEMBL17605544 0.61 SIGMAR1 (0.53) IDO1TACR1SIGMAR1POLB
SCHEMBL8835992 0.61 SIGMAR1 (0.44) IDO1ACHETACR1SIGMAR1POLB
SCHEMBL16268929 0.61 SIGMAR1 (0.44) IDO1TACR1SIGMAR1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5716904-A FOR BROARD LEAF WEEDS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1998-02-10 US disclosed
EP-0764641-A1 NOVEL 4,5-DISUBSTITUTED PYRIMIDINE DERIVATIVE AND HERBICIDE NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1997-03-26 EP disclosed
CN-1133589-A Novel pyrimidine derivative, herbicide and plant growth regulator NISSAN CHEMICAL IND LTD (JP) 1996-10-16 CN disclosed