SCHEMBL8566653

SCHEMBL8566653

OC[C@H](O)COc1cccc2ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 7/20 1.00
KDM4E B2RXH2 2/20 1.00
CYP2C19 P33261 2/20 1.00
MEN1 O00255 1/20 1.00
KMT2A Q03164 1/20 1.00
NR2E1 Q9Y466 5/20 0.73
ADRB2 P07550 4/20 0.64
ADRB1 P08588 4/20 0.64
SIGMAR1 Q99720 4/20 0.64
CYP2D6 P10635 4/20 0.64
SLC6A4 P31645 3/20 0.64
HTR2B P41595 3/20 0.64
ALDH1A1 P00352 3/20 0.64
ADRB3 P13945 3/20 0.64
HTR2A P28223 3/20 0.64
HTR2C P28335 3/20 0.64
HTR6 P50406 3/20 0.64
LMNA P02545 3/20 0.64
SCN1A P35498 2/20 0.64
SLC10A1 Q14973 2/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6483890 1.00 CYP1A2 (1.00) CYP1A2KDM4ECYP2C19MEN1KMT2A
SCHEMBL6483883 1.00 CYP1A2 (1.00) CYP1A2KDM4ECYP2C19MEN1KMT2A
SCHEMBL29437209 1.00 CYP1A2 (1.00) CYP1A2KDM4ECYP2C19MEN1KMT2A
SCHEMBL1394219 0.91 CYP1A2 (0.83) CYP1A2KDM4ECYP2C19MEN1KMT2A
SCHEMBL29437208 0.91 CYP1A2 (0.83) CYP1A2KDM4ECYP2C19MEN1KMT2A
SCHEMBL27902830 0.85 CYP1A2 (0.74) CYP1A2KDM4ECYP2C19MEN1KMT2A
SCHEMBL773269 0.85 NR2E1 (1.00) CYP1A2KDM4ECYP2C19MEN1KMT2A
SCHEMBL8539878 0.85 CYP1A2 (0.73) CYP1A2KDM4ECYP2C19MEN1KMT2A
SCHEMBL9777763 0.85 NR2E1 (1.00) CYP1A2KDM4ECYP2C19MEN1KMT2A
SCHEMBL9777869 0.85 NR2E1 (1.00) CYP1A2KDM4ECYP2C19MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0643781-B1 ELECTROCATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINIC COMPOUNDS SEPRACOR INC (US) 1998-06-24 EP claimed
EP-0643781-A1 ELECTROCATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINIC COMPOUNDS SEPRACOR, INC. (US) 1995-03-22 EP claimed
WO-1993017150-A1 ELECTROCATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINIC COMPOUNDS SEPRACOR, INC. (US) 1993-09-02 WO claimed
EP-0643781-B1 ELECTROCATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINIC COMPOUNDS SEPRACOR INC (US) 1998-06-24 EP disclosed
US-5419817-A Osmium tetroxide catalyst; preparing hydroxycarbonyl compounds from enol ether or vinyl halide SEPRACOR INC. (US) 1995-05-30 US disclosed
EP-0643781-A1 ELECTROCATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINIC COMPOUNDS SEPRACOR, INC. (US) 1995-03-22 EP disclosed
US-5302257-A Preparing optically active glycols using catalyst complex of osmium tetroxide and chiral oxidation resistant tertiary amine, employing secondary oxidant to generate osmium tetroxide, electrolytically regenerating secondary oxidant SEPRACOR, INC. (US) 1994-04-12 US disclosed
WO-1993017150-A1 ELECTROCATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINIC COMPOUNDS SEPRACOR, INC. (US) 1993-09-02 WO disclosed
EP-0248879-A4 SYNTHESIS OF ARYLOXYPROPANOLAMINES AND ARYLETHANOLAMINES. DU PONT (US) 1990-02-26 EP disclosed
US-4900847-A Catalytic asymmetric epoxidation MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1990-02-13 US disclosed
EP-0248879-A1 SYNTHESIS OF ARYLOXYPROPANOLAMINES AND ARYLETHANOLAMINES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1987-12-16 EP disclosed
WO-1987003583-A1 SYNTHESIS OF ARYLOXYPROPANOLAMINES AND ARYLETHANOLAMINES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1987-06-18 WO disclosed
EP-0197766-A2 Catalytic asymmetric epoxidation MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1986-10-15 EP disclosed