Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566683 | 1.00 | TSHR (0.41) | TSHRALDH1A1KDM4ENPSR1L3MBTL1 | |
| SCHEMBL8566723 | 1.00 | TSHR (0.41) | TSHRALDH1A1KDM4ENPSR1L3MBTL1 | |
| SCHEMBL8563625 | 0.84 | BACE1 (0.41) | TSHRALDH1A1KDM4ENPSR1L3MBTL1 | |
| SCHEMBL8563627 | 0.84 | BACE1 (0.41) | TSHRALDH1A1KDM4ENPSR1L3MBTL1 | |
| SCHEMBL8563622 | 0.84 | BACE1 (0.41) | TSHRALDH1A1KDM4ENPSR1L3MBTL1 | |
| SCHEMBL8584722 | 0.84 | TSHR (0.47) | TSHRALDH1A1L3MBTL1MAPK1GAA | |
| SCHEMBL22777395 | 0.82 | POLB (0.44) | TSHRALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL26783404 | 0.81 | GAA (0.42) | ALDH1A1KDM4ENPSR1HSD17B10CYP1A2 | |
| SCHEMBL7302983 | 0.78 | L3MBTL1 (0.47) | TSHRALDH1A1KDM4ENPSR1L3MBTL1 | |
| SCHEMBL28878047 | 0.77 | GAA (0.53) | ALDH1A1CYP2C19GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |