Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MOGAT2 | Q3SYC2 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17363665 | 0.86 | GAA (0.48) | GAACYP1A2MOGAT2TSHRHSD17B10 | |
| SCHEMBL17363918 | 0.84 | KMT2A (0.43) | L3MBTL1GAACYP1A2ALDH1A1MEN1 | |
| SCHEMBL24776515 | 0.83 | L3MBTL1 (0.46) | L3MBTL1CYP1A2ALDH1A1MEN1MAPT | |
| SCHEMBL17363661 | 0.83 | L3MBTL1 (0.46) | L3MBTL1CYP1A2ALDH1A1MEN1MAPT | |
| SCHEMBL7298355 | 0.80 | GAA (0.52) | GAAMOGAT2HSD17B10ALDH1A1MEN1 | |
| SCHEMBL8566723 | 0.78 | TSHR (0.41) | L3MBTL1GAACYP1A2TSHRHSD17B10 | |
| SCHEMBL8566683 | 0.78 | TSHR (0.41) | L3MBTL1GAACYP1A2TSHRHSD17B10 | |
| SCHEMBL8566682 | 0.78 | TSHR (0.41) | L3MBTL1GAACYP1A2TSHRHSD17B10 | |
| SCHEMBL6711082 | 0.77 | CYP1A2 (0.49) | GAACYP1A2TSHRHSD17B10ALDH1A1 | |
| SCHEMBL11327486 | 0.77 | GAA (0.57) | GAAMOGAT2MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666260-B1 | 3-(2-aminoethyl)-4-3-(trifluoromethyl)benzoyl-3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and use in therapy | SYNTHELABO (FR) | 1999-08-04 | — | — | EP | claimed |
| EP-0614893-B1 | Benzoxazine derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1998-05-27 | — | — | EP | claimed |
| EP-3160948-B1 | BENZOXAZINONE AMIDES AS MINERALOCORTICOID RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2018-10-24 | — | — | EP | disclosed |
| US-10017502-B2 | Benzoxazinone amides as mineralocorticoid receptor modulators | ASTRAZENECA AB (SE) | 2018-07-10 | — | — | US | disclosed |
| US-20170217945-A1 | BENZOXAZINONE AMIDES AS MINERALOCORTICOID RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2017-08-03 | — | — | US | disclosed |
| EP-3160948-A1 | BENZOXAZINONE AMIDES AS MINERALOCORTICOID RECEPTOR MODULATORS | Astrazeneca AB (SE) | 2017-05-03 | — | — | EP | disclosed |
| EP-2686306-B1 | BENZO[B][1,4]OXAZIN DERIVATIVES AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN ATLANTIS HOLDINGS SA (CH) | 2017-01-04 | — | — | EP | disclosed |
| US-9464063-B2 | Benzo [B] [1,4] oxazin derivatives as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-10-11 | — | — | US | disclosed |
| US-9464063-B2 | Benzo [B] [1,4] oxazin derivatives as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-10-11 | — | — | US | disclosed |
| US-9394291-B2 | Benzoxazinone amides as mineralocorticoid receptor modulators | ASTRAZENECA AB (SE) | 2016-07-19 | — | — | US | disclosed |
| WO-2016001631-A1 | BENZOXAZINONE AMIDES AS MINERALOCORTICOID RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2016-01-07 | — | — | WO | disclosed |
| US-8268814-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2012-09-18 | — | — | US | disclosed |
| US-8268814-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2012-09-18 | — | — | US | disclosed |
| US-20090275558-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-11-05 | — | — | US | disclosed |
| US-20090275558-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-11-05 | — | — | US | disclosed |
| US-20090264400-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2009-10-22 | — | — | US | disclosed |
| US-20090264400-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2009-10-22 | — | — | US | disclosed |
| WO-2009124746-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2009-10-15 | — | — | WO | disclosed |
| WO-2009124733-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-10-15 | — | — | WO | disclosed |
| US-5447928-A | Antiischemic agents and nervous system disorders | SYNTHELABO (FR) | 1995-09-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217945-A1 | BENZOXAZINONE AMIDES AS MINERALOCORTICOID RECEPTOR MODULATORS | NR3C2, CYP11B1, CYP11B2 | L3MBTL1 4884/4885GAA 3448/4885CYP1A2 226/4885 |
| US-10017502-B2 | Benzoxazinone amides as mineralocorticoid receptor modulators | NR3C2, CYP11B1, CYP11B2 | L3MBTL1 4884/4885GAA 3448/4885CYP1A2 226/4885 |
| US-20090275558-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | BDKRB2, BDKRB1, TRPV1 | L3MBTL1 4835/4885GAA 3388/4885CYP1A2 1996/4885 |
| US-20090264400-A1 | Substituted Sulfonamide Compounds | BDKRB1, BDKRB2, TRPV1 | L3MBTL1 4855/4885GAA 2852/4885CYP1A2 1494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.