SCHEMBL8566727

SCHEMBL8566727

Brc1ccc(-c2ccncn2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.51
RAB9A P51151 5/20 0.46
SMN1; SMN2 Q16637 4/20 0.46
KDM4E B2RXH2 3/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
LMNA P02545 1/20 0.46
MAPT P10636 3/20 0.41
HDAC4 P56524 1/20 0.40
METAP2 P50579 1/20 0.39
MAPK10 P53779 2/20 0.39
MAPK14 Q16539 2/20 0.39
PIK3CA P42336 2/20 0.39
PIK3CB P42338 2/20 0.39
PIK3CG P48736 2/20 0.39
NPC1 O15118 4/20 0.39
NFKB1 P19838 1/20 0.39
MAPK1 P28482 1/20 0.39
NFKB2 Q00653 1/20 0.39
RELA Q04206 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30273511 1.00 CYP2D6 (0.51) CYP2D6RAB9ASMN1; SMN2KDM4EMEN1
SCHEMBL28078259 0.98 CYP2D6 (0.50) CYP2D6RAB9ASMN1; SMN2KDM4EMEN1
SCHEMBL9903935 0.89 CYP2D6 (0.60) CYP2D6LMNAMAPTHDAC4MAPK10
SCHEMBL8695286 0.82 CYP2D6 (0.60) CYP2D6RAB9ASMN1; SMN2KDM4EMEN1
SCHEMBL8499115 0.81 CYP2D6 (0.53) CYP2D6RAB9ALMNAMAPTMAPK10
SCHEMBL28135256 0.81 MAPK14 (0.40) CYP2D6RAB9ASMN1; SMN2KDM4EMEN1
SCHEMBL15651713 0.78 CYP2D6 (0.51) CYP2D6RAB9ASMN1; SMN2KDM4EMEN1
SCHEMBL675705 0.78 CYP2D6 (0.51) CYP2D6MAPTHDAC4MAPK10MAPK14
SCHEMBL2562967 0.78 CYP2D6 (0.56) CYP2D6RAB9ASMN1; SMN2KDM4EMEN1
SCHEMBL1061567 0.78 CYP2D6 (0.51) CYP2D6MAPTHDAC4METAP2MAPK10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4737448-A1 SARM1 ENZYME ACTIVITY INHIBITOR AND USE THEREOF Artivila (ShenZhen) Innovation Center, Ltd. (CN) 2026-05-06 EP disclosed
WO-2025002030-A1 SARM1 ENZYME ACTIVITY INHIBITOR AND USE THEREOF 科辉智药(深圳)新药研究中心有限公司 2025-01-02 WO disclosed
CN-100577649-C Electroluminescent device CIBA SC HOLDING AG 2010-01-06 CN disclosed
CN-1708485-A Electroluminescent device CIBA SC HOLDING AG (CH) 2005-12-14 CN disclosed
US-5780473-A Substituted biphenyl sulfonamide endothelin antagonists BRISTOL-MYERS SQUIBB COMPANY (US) 1998-07-14 US disclosed
US-5760038-A Substituted biphenyl sulfonamide endothelin antagonists BRISTOL-MYERS SQUIBB COMPANY (US) 1998-06-02 US disclosed
EP-0725067-A1 Substituted biphenyl sulfonamide endothelin antagonists BRISTOL-MYERS SQUIBB COMPANY (US) 1996-08-07 EP disclosed
EP-0508999-A1 PHARMACEUTICALLY ACTIVE NORMONYL COMPOUNDS Beecham Group p.l.c. (GB) 1992-10-21 EP disclosed
WO-1991009855-A1 PHARMACEUTICALLY ACTIVE NORMONYL COMPOUNDS BEECHAM GROUP PLC (GB) 1991-07-11 WO disclosed