Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 11/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566783 | 1.00 | CD38 (0.43) | CD38EGFRERBB2IRAK4MKNK1 | |
| SCHEMBL6988137 | 0.80 | BRAF (0.53) | CD38EGFRERBB2 | |
| SCHEMBL7001817 | 0.80 | BRAF (0.53) | CD38EGFRERBB2 | |
| SCHEMBL8567653 | 0.77 | EGFR (0.61) | EGFRERBB2MEN1KMT2AJAK3 | |
| SCHEMBL8567648 | 0.77 | EGFR (0.61) | EGFRERBB2MEN1KMT2AJAK3 | |
| SCHEMBL6999541 | 0.75 | EGFR (0.52) | EGFRERBB2 | |
| SCHEMBL6999546 | 0.75 | EGFR (0.52) | EGFRERBB2 | |
| SCHEMBL8568476 | 0.72 | EGFR (0.47) | EGFRERBB2MKNK1MEN1KMT2A | |
| SCHEMBL8314236 | 0.72 | BRAF (0.54) | CD38EGFRERBB2MKNK1JAK3 | |
| SCHEMBL8314239 | 0.72 | BRAF (0.54) | CD38EGFRERBB2MKNK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885226-A1 | 4-AMINO PYRIMIDINE DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032881-A1 | 4-AMINO PYRIMIDINE DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |