Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.40 |
| ▸ | BACE1 | P56817 | 3/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857760 | 0.91 | CLK4 (0.43) | PDGFRBPIK3CAMAPK1LMNACYP3A4 | |
| SCHEMBL855635 | 0.88 | NCF1 (0.40) | PDGFRBPIK3CAKDR | |
| SCHEMBL859565 | 0.88 | PIK3CA (0.41) | PIK3CAMAPK1LMNACYP3A4CYP2D6 | |
| SCHEMBL3714926 | 0.87 | PDGFRB (0.44) | PDE10APDGFRBGAKACHEBACE1 | |
| SCHEMBL857984 | 0.85 | PDE10A (0.48) | PDE10APDGFRBGAKACHEBACE1 | |
| SCHEMBL7859686 | 0.85 | PDE10A (0.44) | PDE10AAURKAPDGFRBGAKACHE | |
| SCHEMBL15522613 | 0.85 | PIK3CA (0.40) | PIK3CAKIT | |
| SCHEMBL856104 | 0.82 | CREBBP (0.46) | PIK3CA | |
| SCHEMBL861756 | 0.81 | PDE10A (0.44) | PDE10APDGFRBGAKACHEBACE1 | |
| SCHEMBL857762 | 0.81 | PIK3CA (0.47) | PDE10APDGFRBGAKACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |