Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.43 |
| ▸ | USP2 | O75604 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | GPR142 | Q7Z601 | 5/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856679 | 0.91 | PDE10A (0.42) | CLK4CYP3A4LMNACYP2D6MAPK1 | |
| SCHEMBL859565 | 0.90 | PIK3CA (0.41) | CLK4CYP3A4CYP1A2USP2LMNA | |
| SCHEMBL3716243 | 0.87 | MTNR1B (0.44) | CLK4CYP3A4CYP1A2USP2LMNA | |
| SCHEMBL858599 | 0.85 | CYP2C19 (0.49) | CLK4CYP3A4CYP1A2USP2LMNA | |
| SCHEMBL13056673 | 0.85 | MTNR1B (0.44) | CLK4CYP3A4CYP1A2USP2LMNA | |
| SCHEMBL15522613 | 0.85 | PIK3CA (0.40) | PIK3CAKIT | |
| SCHEMBL856104 | 0.82 | CREBBP (0.46) | PIK3CAGPR142 | |
| SCHEMBL15522763 | 0.80 | PIK3CA (0.44) | PIK3CAGPR142 | |
| SCHEMBL3756056 | 0.80 | PIK3CA (0.43) | PIK3CAGPR142 | |
| SCHEMBL857379 | 0.80 | PIK3CA (0.47) | CLK4CYP3A4CYP1A2USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |