Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | SMO | Q99835 | 8/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16648653 | 0.86 | KMT2A (0.52) | KMT2AATMCES2CFTRNPC1 | |
| SCHEMBL5654548 | 0.84 | KMT2A (0.51) | KMT2AATMSMOCES2HCRTR1 | |
| SCHEMBL13166715 | 0.83 | KMT2A (0.46) | KMT2AATMCES2CFTRSMN1; SMN2 | |
| SCHEMBL29175212 | 0.82 | KMT2A (0.49) | KMT2AATMSMOCES2HCRTR1 | |
| SCHEMBL18837984 | 0.81 | ALDH1A1 (0.54) | KMT2AATMCES2CFTRSMN1; SMN2 | |
| SCHEMBL16044918 | 0.81 | CFTR (0.48) | KMT2AATMCES2CFTRSMN1; SMN2 | |
| SCHEMBL30133947 | 0.80 | KMT2A (0.49) | KMT2AATMSMOCES2HCRTR1 | |
| SCHEMBL2074860 | 0.80 | KMT2A (0.49) | KMT2AATMSMOCES2HCRTR1 | |
| SCHEMBL28462767 | 0.80 | KMT2A (0.55) | KMT2AATMCES2HCRTR1HCRTR2 | |
| SCHEMBL334641 | 0.80 | KEAP1 (0.52) | KMT2AATMCES2HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | claimed |