Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 7/20 | 0.51 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.49 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31514587 | 0.80 | EGFR (0.54) | CDK1CDK2SMG1EGFRHTT | |
| SCHEMBL8871984 | 0.80 | EGFR (0.58) | MAPTTP53POLBEGFRTTBK1 | |
| Hydrochloric Acid SCHEMBL8871612 | 0.77 | MAPK1 (0.63) | MAPTEGFRTTBK1TTBK2HTT | |
| SCHEMBL8870722 | 0.75 | EGFR (0.57) | EGFRTTBK1TTBK2HTTHIF1A | |
| SCHEMBL8319713 | 0.74 | EGFR (0.66) | SRCMAPTTP53POLBEGFR | |
| SCHEMBL8597502 | 0.72 | EGFR (0.55) | MAPTEGFRPIK3CDPIK3CBHTT | |
| SCHEMBL8870749 | 0.71 | ALDH1A1 (0.60) | MAPTEGFRLMNAMAPK1ERBB2 | |
| SCHEMBL8872015 | 0.71 | EGFR (0.64) | EGFRHTTHIF1AMAPK1ERBB2 | |
| SCHEMBL19314794 | 0.69 | EGFR (0.76) | SRCEGFR | |
| SCHEMBL31514581 | 0.69 | EGFR (0.54) | EGFRDGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885226-A1 | 4-AMINO PYRIMIDINE DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032881-A1 | 4-AMINO PYRIMIDINE DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |