Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 5/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | KLK3 | P07288 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615579 | 0.81 | RXRB (0.45) | GAANOTUMKDM4EALDH1A1 | |
| SCHEMBL7324119 | 0.80 | CFTR (0.46) | GAANOTUMKDM4EALDH1A1LMNA | |
| SCHEMBL30291135 | 0.76 | PLK1 (0.51) | GAANOTUMALDH1A1PLK1POLB | |
| SCHEMBL8573469 | 0.75 | GAA (0.53) | GAAKDM4EHTTRXFP1ALDH1A1 | |
| SCHEMBL28119410 | 0.75 | GAA (0.49) | GAANOTUMKDM4EHTTRXFP1 | |
| SCHEMBL5953962 | 0.72 | GAA (0.69) | GAAALDH1A1PDK2PLK1SMN1; SMN2 | |
| SCHEMBL17806029 | 0.71 | AR (0.32) | AR | |
| SCHEMBL14214021 | 0.71 | KDM4E (0.53) | GAAKDM4EHTTRXFP1ALDH1A1 | |
| SCHEMBL13407781 | 0.71 | KDM4E (0.64) | GAAKDM4EHTTRXFP1ALDH1A1 | |
| SCHEMBL18530548 | 0.71 | PLK1 (0.49) | GAARXFP1ALDH1A1PLK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | claimed |