Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 3/20 | 0.45 |
| ▸ | CES1 | P23141 | 3/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 2/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6394342 | 0.84 | CES2 (0.59) | GAACES2CES1PLK1NUDT1 | |
| SCHEMBL22576727 | 0.81 | GAA (0.46) | GAAHDAC4PLK1HTTALDH1A1 | |
| SCHEMBL30856362 | 0.80 | LMNA (0.42) | GAACES2CES1HDAC4HTT | |
| SCHEMBL7453388 | 0.79 | GAA (0.52) | GAACES2CES1PLK1NUDT1 | |
| SCHEMBL29465861 | 0.78 | CES2 (0.50) | CES2CES1HDAC4ALDH1A1BCHE | |
| SCHEMBL26771499 | 0.78 | CES2 (0.50) | CES2CES1HDAC4RXFP1PKM | |
| SCHEMBL107175 | 0.78 | CES2 (0.50) | CES2CES1HDAC4ALDH1A1BCHE | |
| SCHEMBL5953962 | 0.77 | GAA (0.69) | GAACES2CES1PLK1ALDH1A1 | |
| SCHEMBL8572283 | 0.77 | GAA (0.48) | GAACES2CES1PLK1NUDT1 | |
| SCHEMBL8217125 | 0.77 | CES2 (0.50) | GAACES2CES1HDAC4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | claimed |
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |