SCHEMBL8566909

SCHEMBL8566909

Cc1ccccc1CCN(CNS(=O)(=O)c1ccccc1-c1ccc(-c2ncco2)cc1)c1onc(C)c1C

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EDNRA P25101 19/20 0.57
EDNRB P24530 19/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8569192 0.74 EDNRA (0.56) EDNRAEDNRB
SCHEMBL4204130 0.73 EDNRB (1.00) EDNRAEDNRB
SCHEMBL8572335 0.73 EDNRA (0.60) EDNRAEDNRB
SCHEMBL8568208 0.70 EDNRA (0.55) EDNRAEDNRB
SCHEMBL6639043 0.69 EDNRA (0.54) EDNRAEDNRB
SCHEMBL8569947 0.69 EDNRB (0.52) EDNRAEDNRB
SCHEMBL8566286 0.69 EDNRA (0.58) EDNRAEDNRB
SCHEMBL6641243 0.69 EDNRA (0.54) EDNRAEDNRB
SCHEMBL8570228 0.68 EDNRA (0.51) EDNRAEDNRB
SCHEMBL8568596 0.68 EDNRA (0.50) EDNRAEDNRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5846990-A Substituted biphenyl isoxazole sulfonamides BRISTOL-MYERS SQUIBB CO. (US) 1998-12-08 US disclosed