Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 17/20 | 0.58 |
| ▸ | EDNRB | P24530 | 16/20 | 0.58 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.42 |
| ▸ | FEN1 | P39748 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8720322 | 0.84 | EDNRA (0.53) | EDNRAEDNRB | |
| SCHEMBL7506365 | 0.79 | EDNRA (0.45) | EDNRAEDNRBALOX5APFEN1 | |
| SCHEMBL8568208 | 0.78 | EDNRA (0.55) | EDNRAEDNRB | |
| SCHEMBL7868303 | 0.76 | EDNRB (0.56) | EDNRAEDNRB | |
| SCHEMBL6986037 | 0.76 | EDNRB (0.56) | EDNRAEDNRBALOX5APFEN1 | |
| SCHEMBL4204130 | 0.73 | EDNRB (1.00) | EDNRAEDNRB | |
| SCHEMBL8566290 | 0.72 | EDNRA (0.51) | EDNRAEDNRB | |
| SCHEMBL8717479 | 0.72 | EDNRA (0.52) | EDNRAEDNRB | |
| SCHEMBL7508467 | 0.72 | EDNRB (0.50) | EDNRAEDNRBALOX5APFEN1 | |
| SCHEMBL1804383 | 0.71 | HPGDS (0.56) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |
| US-5827869-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-10-27 | — | — | US | disclosed |