Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SOD1 | P00441 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18118971 | 0.84 | CYP3A4 (0.59) | CYP3A4CYP2C9CYP2C19SOD1POLB | |
| SCHEMBL919095 | 0.83 | TEAD1 (0.46) | CYP2C9CYP2C19POLBL3MBTL1MAPT | |
| SCHEMBL2261145 | 0.83 | CYP2C9 (0.49) | CYP3A4CYP2C9CYP2C19SOD1POLB | |
| SCHEMBL512275 | 0.83 | MAPT (0.52) | POLBLMNAHTTL3MBTL1MAPT | |
| SCHEMBL15576545 | 0.82 | CYP3A4 (0.57) | CYP3A4CYP2C9CYP2C19SOD1POLB | |
| SCHEMBL5671239 | 0.78 | CYP2C9 (0.54) | CYP3A4CYP2C9CYP2C19SOD1POLB | |
| SCHEMBL8155454 | 0.78 | LTA4H (0.43) | MAPTALDH1A1 | |
| SCHEMBL920806 | 0.77 | SMN1; SMN2 (0.53) | CYP3A4POLBALDH1A1ACHE | |
| SCHEMBL919378 | 0.77 | ALDH1A1 (0.53) | LMNAHTTL3MBTL1MAPTALDH1A1 | |
| SCHEMBL6154747 | 0.77 | CYP3A4 (0.42) | CYP3A4POLBLMNAHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |