Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 5/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.59 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL243150 | 0.83 | KCNJ1 (0.53) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 | |
| SCHEMBL14945089 | 0.80 | KCNJ1 (0.59) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 | |
| SCHEMBL2095110 | 0.80 | KCNJ1 (0.59) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 | |
| SCHEMBL8190246 | 0.80 | KCNJ1 (0.59) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 | |
| SCHEMBL8563448 | 0.80 | KCNJ1 (0.59) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 | |
| SCHEMBL24425019 | 0.77 | KCNJ1 (0.56) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 | |
| SCHEMBL4948659 | 0.77 | KCNJ1 (0.56) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 | |
| SCHEMBL3271828 | 0.75 | KCNJ1 (0.53) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 | |
| SCHEMBL8913108 | 0.75 | ENPP2 (0.54) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 | |
| SCHEMBL8256316 | 0.75 | KCNJ1 (0.53) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1537105-A | Quinazolines useful as MMP-13 inhibitors | ��������ʲ��������ι�˾ | 2004-10-13 | — | — | CN | disclosed |
| EP-0431943-B1 | Spiro(pyran)piperidine derivatives | MERCK & CO INC (US) | 1998-07-15 | — | — | EP | disclosed |
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| US-5112824-A | Benzofurazan compounds | MERCK & CO., INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5032604-A | Class III antiarrhythmic agents | MERCK & CO., INC. (US) | 1991-07-16 | — | — | US | disclosed |
| EP-0431944-A2 | Benzofurazan derivatives having antiarrhythmic properties | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |
| EP-0431943-A2 | Nitrogen-containing spirocycles | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |