Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 4/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.53 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8567072 | 0.83 | KCNJ1 (0.59) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 | |
| SCHEMBL2093216 | 0.78 | KCNJ1 (0.53) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 | |
| SCHEMBL13610285 | 0.78 | KCNJ1 (0.53) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 | |
| SCHEMBL16373414 | 0.78 | KCNJ1 (0.53) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 | |
| SCHEMBL2056122 | 0.78 | KCNJ1 (0.53) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 | |
| SCHEMBL8256316 | 0.78 | KCNJ1 (0.53) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 | |
| SCHEMBL8913108 | 0.78 | ENPP2 (0.54) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 | |
| SCHEMBL3271828 | 0.78 | KCNJ1 (0.53) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 | |
| Hydrochloric Acid SCHEMBL19119426 | 0.77 | PKM (0.54) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 | |
| SCHEMBL2731118 | 0.75 | KCNJ1 (0.50) | KCNJ1KCNH2ENPP2ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 168 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240360082-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2024-10-31 | — | — | US | disclosed |
| CN-114591226-B | Preparation method of nicotinaldehyde derivative | 南京益恩生物科技有限公司 | 2024-09-17 | — | — | CN | disclosed |
| CN-116730940-B | Heterocyclic substituted biphenyl compound and medical application thereof | 中国药科大学 | 2024-08-30 | — | — | CN | disclosed |
| US-20240287070-A1 | FUSED HETEROCYCLIC DERIVATIVES | JOHNSON & JOHNSON (CHINA) INVESTMENT LTD. (CN) | 2024-08-29 | — | — | US | disclosed |
| EP-4373809-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | Novartis AG (CH) | 2024-05-29 | — | — | EP | disclosed |
| CN-117986158-A | Substituted biphenyl compound, preparation method and application | 云南大学 | 2024-05-07 | — | — | CN | disclosed |
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| EP-4347590-A1 | FUSED HETEROCYCLIC DERIVATIVES | Janssen Sciences Ireland Unlimited Company (IE) | 2024-04-10 | — | — | EP | disclosed |
| CN-116730940-A | Heterocyclic substituted biphenyl compound and medical application thereof | 中国药科大学 | 2023-09-12 | — | — | CN | disclosed |
| US-11725000-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-08-15 | — | — | US | disclosed |
| EP-0640595-B1 | SUBSTITUTED TERTIARY AMINO COMPOUND OR SALT THEREOF | YAMANOUCHI PHARMA CO LTD (JP) | 1999-03-24 | — | — | EP | disclosed |
| WO-1999000669-A1 | NUCLEOBASE HETEROCYCLIC COMBINATORIALIZATION | ISIS PHARMACEUTICALS, INC. (US) | 1999-01-07 | — | — | WO | disclosed |
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| US-5808139-A | CONTROLLING COMPLEXING WITH CYMOPOLY COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1998-09-15 | — | — | US | disclosed |
| US-5674886-A | AROMATASE INHIBITOR; BREAST CANCER; UROGENITAL DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1997-10-07 | — | — | US | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |
| US-5538976-A | ANTICARCINOGENIC AGENTS AND ENZYME INHIBITORS FOR AROMATASE | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1996-07-23 | — | — | US | disclosed |
| EP-0641785-A1 | TRIAZOLYLATED TERTIARY AMINE COMPOUND OR SALT THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1995-03-08 | — | — | EP | disclosed |
| EP-0640595-A1 | NOVEL SUBSTITUTED TERTIARY AMINO COMPOUND OR SALT THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1995-03-01 | — | — | EP | disclosed |
| WO-1994024080-A1 | PROGESTERONE RECEPTOR AGONIST AND ANTAGONISTS | LIGAND PHARMACEUTICALS INC. (US) | 1994-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11725000-B2 | Apoptosis inhibitors | BAX, SDHA, SDHB | KCNJ1 3934/4885KCNH2 3722/4885ENPP2 3156/4885 |
| US-20240287070-A1 | FUSED HETEROCYCLIC DERIVATIVES | HAVCR2, HCCS, GOT2 | KCNJ1 4552/4885KCNH2 4443/4885ENPP2 2197/4885 |
| US-20240360082-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | PNPO, PDXK, PLPBP | KCNJ1 1539/4885KCNH2 1919/4885ENPP2 1619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.