Pyridine

Pyridine

SCHEMBL8567227

NC(=O)NC(N)=O.c1ccncc1

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NAPRT Q6XQN6 2/20 0.47
TSHR P16473 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
RECQL P46063 1/20 0.38
HTT P42858 1/20 0.38
CRBN Q96SW2 1/20 0.38
JAK2 O60674 1/20 0.38
TYK2 P29597 1/20 0.38
F7 P08709 1/20 0.37
F3 P13726 1/20 0.37
SARM1 Q6SZW1 1/20 0.37
SIRT2 Q8IXJ6 1/20 0.37
SIRT6 Q8N6T7 1/20 0.37
SIRT1 Q96EB6 1/20 0.37
SIRT3 Q9NTG7 1/20 0.37
SIRT5 Q9NXA8 1/20 0.37
SIRT4 Q9Y6E7 1/20 0.37
ALDH1A1 P00352 2/20 0.35
CYP1A2 P05177 2/20 0.35
CYP3A4 P08684 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyridine SCHEMBL9333935 0.86 CRBN (0.61) NAPRTTSHRTDP1RECQLHTT
Pyrazine SCHEMBL9690748 0.86 CRBN (0.43) NAPRTTSHRRECQLHTTCRBN
Pyridine SCHEMBL27474885 0.84 CYP1A2 (0.53) NAPRTTSHRTDP1RECQLHTT
Pyridine SCHEMBL1164077 0.83 NAPRT (0.60) NAPRTTSHRTDP1RECQLF7
Pyridine SCHEMBL1070164 0.83 NAPRT (0.60) NAPRTTSHRTDP1RECQLHTT
Pyridine SCHEMBL9065525 0.83 NAPRT (0.60) NAPRTTSHRTDP1RECQLF7
Benzene SCHEMBL27729594 0.83 CRBN (0.50) TSHRTDP1RECQLCRBNALDH1A1
Pyridine SCHEMBL28762997 0.82 TSHR (0.45) NAPRTTSHRTDP1RECQLHTT
Pyridine SCHEMBL27497756 0.82 NAPRT (0.45) NAPRTTSHRTDP1RECQLHTT
Pyridine SCHEMBL28762998 0.80 NAPRT (0.56) NAPRTTSHRTDP1RECQLHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106188047-A One prepares the method for 6 (1 phenylethyl) pyrrolo-[3,4 b] pyridine 5,7 diketone 上海沃凯生物技术有限公司 2016-12-07 CN disclosed
CN-106188047-A One prepares the method for 6 (1 phenylethyl) pyrrolo-[3,4 b] pyridine 5,7 diketone 上海沃凯生物技术有限公司 2016-12-07 CN disclosed
EP-0663399-B1 Pyridine-2,3-dicarboxylic imides, process for their preparation and their use to control the growth of unwanted plants BASF AG (DE) 1998-06-10 EP disclosed
EP-0661282-B1 Pyridine-2,3-dicarboxylic imides, process for their preparation and their use to control the growth of unwanted plants BASF AG (DE) 1998-04-22 EP disclosed
EP-0663399-A1 Pyridine-2,3-dicarboxylic imides, process for their preparation and their use to control the growth of unwanted plants BASF AKTIENGESELLSCHAFT (DE) 1995-07-19 EP disclosed
EP-0661282-A1 Pyridine-2,3-dicarboxylic imides, process for their preparation and their use to control the growth of unwanted plants BASF AKTIENGESELLSCHAFT (DE) 1995-07-05 EP disclosed
EP-0422456-B1 Pyridine derivatives and their use in combating unwanted plant growth BASF AG (DE) 1995-05-03 EP disclosed
EP-0422456-A2 Pyridine derivatives and their use in combating unwanted plant growth BASF Aktiengesellschaft (DE) 1991-04-17 EP disclosed