Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6761097 | 0.93 | ALDH1A1 (0.43) | TSHRMAPK1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8568524 | 0.93 | TSHR (0.43) | TSHRMAPK1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8572990 | 0.90 | KDM4E (0.46) | TSHRMAPK1ALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL6757740 | 0.88 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2NPC1RAB9ARECQL | |
| SCHEMBL14647559 | 0.88 | KDM4E (0.52) | ALDH1A1SMN1; SMN2NPC1RAB9AHSD17B10 | |
| SCHEMBL10840353 | 0.88 | SMN1; SMN2 (0.43) | TSHRMAPK1ALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL8571891 | 0.85 | SMN1; SMN2 (0.53) | TSHRMAPK1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL6762411 | 0.81 | ALDH1A1 (0.44) | TSHRALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8565133 | 0.80 | ALDH1A1 (0.61) | TSHRMAPK1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8573320 | 0.80 | NPC1 (0.44) | TSHRALDH1A1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5705650-A | Process for preparing 1,2,4-thiadiazole derivatives | KATAYAMA SEIYAKUSYO CO., LTD. (JP) | 1998-01-06 | — | — | US | disclosed |
| US-5585494-A | Process for preparing 1,2,4-thiadiazole derivatives | KATAYAMA SEIYAKUSYO CO. LTD. (JP) | 1996-12-17 | — | — | US | disclosed |
| EP-0536900-A2 | Process for preparing 1,2,4-Thiadiazole Derivatives | KATAYAMA SEIYAKUSYO CO. Ltd. (JP) | 1993-04-14 | — | — | EP | disclosed |