SCHEMBL8567767

SCHEMBL8567767

CCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Cl)c(C)nc23)c1Cl

nearest known ligand 0.85

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 13/20 0.85

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8564124 0.99 BDKRB2 (0.84) BDKRB2
SCHEMBL8562889 0.92 BDKRB2 (1.00) BDKRB2
Hydrochloric Acid SCHEMBL8566695 0.91 BDKRB2 (0.98) BDKRB2
SCHEMBL8559826 0.90 BDKRB2 (0.85) BDKRB2
Hydrochloric Acid SCHEMBL8560592 0.89 BDKRB2 (0.86) BDKRB2
Hydrochloric Acid SCHEMBL8560297 0.89 BDKRB2 (0.84) BDKRB2
SCHEMBL8565007 0.89 BDKRB2 (0.72) BDKRB2
Hydrochloric Acid SCHEMBL8563666 0.88 BDKRB2 (0.72) BDKRB2
SCHEMBL8561535 0.88 BDKRB2 (0.67) BDKRB2
Hydrochloric Acid SCHEMBL8566229 0.87 BDKRB2 (0.67) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 EP disclosed
US-5574042-A ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN FUJISAWA PHARMACEUTICAL CO., LTD (JP) 1996-11-12 US disclosed
EP-0596406-A1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 EP disclosed