Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | POLQ | O75417 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12574809 | 0.79 | CYP2D6 (0.48) | HTTNPSR1POLQCYP2D6CYP2C19 | |
| SCHEMBL5113337 | 0.74 | CYP2D6 (0.42) | HTTNPSR1CYP2D6CYP2C19HDAC1 | |
| SCHEMBL1448809 | 0.72 | CYP2D6 (0.41) | HTTNPSR1CYP2D6CYP2C19HDAC1 | |
| SCHEMBL316609 | 0.71 | CYP2D6 (0.48) | HTTNPSR1CYP2D6CYP2C19POLB | |
| SCHEMBL3486119 | 0.70 | CES1 (0.37) | HTTNPSR1POLQCYP2C19ALDH1A1 | |
| SCHEMBL9183264 | 0.69 | ALDH1A1 (0.44) | HTTNPSR1CYP2D6CYP2C19POLB | |
| SCHEMBL31259405 | 0.68 | POLB (0.40) | HTTNPSR1POLQHDAC1HDAC6 | |
| Trifluoroacetic Acid SCHEMBL8029336 | 0.68 | POLQ (0.47) | HTTNPSR1POLQCYP2D6CYP2C19 | |
| SCHEMBL3666841 | 0.67 | TSHR (0.47) | HTTNPSR1POLBALDH1A1KMT2A | |
| SCHEMBL1185718 | 0.67 | CYP2D6 (0.44) | CYP2D6CYP2C19POLBALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |