Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27681165 | 1.00 | RNPEP (0.47) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| SCHEMBL27361292 | 0.98 | RNPEP (0.46) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| SCHEMBL27361290 | 0.98 | RNPEP (0.46) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| SCHEMBL27387943 | 0.89 | RNPEP (0.47) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| SCHEMBL5179354 | 0.86 | RNPEP (0.48) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| SCHEMBL5179360 | 0.86 | RNPEP (0.48) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| SCHEMBL3923641 | 0.85 | LMNA (0.44) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| Iodide SCHEMBL11474184 | 0.85 | LMNA (0.44) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| SCHEMBL128038 | 0.85 | LMNA (0.44) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| Hydrochloric Acid SCHEMBL11456037 | 0.85 | LMNA (0.44) | RNPEPLMNAALDH1A1NPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117689-B1 | BONE MORPHOGENETIC PROTEIN ANTAGONISTS BASED ON THE MATURE PROTEIN | BIOPH BIOTECH ENTW PHARM GMBH (DE) | 2012-03-28 | — | — | EP | disclosed |
| US-7132397-B1 | Bone morphogenetic protein antagonist based on the mature protein | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA MBH (DE) | 2006-11-07 | — | — | US | disclosed |
| EP-1117689-A1 | BONE MORPHOGENETIC PROTEIN ANTAGONISTS BASED ON THE MATURE PROTEIN | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH (DE) | 2001-07-25 | — | — | EP | disclosed |
| US-6156908-A | Procedure for the manufacture of 3-amino-2-oxo-pyrrolidines, new intermediates and their use | ROHM GESELLSCHAFT, GMBH (DE) | 2000-12-05 | — | — | US | disclosed |
| WO-2000021998-A1 | BONE MORPHOGENETIC PROTEIN ANTAGONIST BASED ON THE MATURE PROTEIN | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA MBH (DE) | 2000-04-20 | — | — | WO | disclosed |