Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3923641 | 1.00 | LMNA (0.44) | LMNARNPEPCA2CA1RAB9A | |
| SCHEMBL856817 | 0.85 | RNPEP (0.47) | LMNARNPEPCA2CA1ALDH1A1 | |
| SCHEMBL27681165 | 0.85 | RNPEP (0.47) | LMNARNPEPCA2CA1ALDH1A1 | |
| SCHEMBL27387943 | 0.85 | RNPEP (0.47) | LMNARNPEPCA2CA1RAB9A | |
| SCHEMBL27361292 | 0.84 | RNPEP (0.46) | LMNARNPEPCA2CA1RAB9A | |
| SCHEMBL27361290 | 0.84 | RNPEP (0.46) | LMNARNPEPCA2CA1RAB9A | |
| SCHEMBL5179354 | 0.83 | RNPEP (0.48) | LMNARNPEPCA2CA1RAB9A | |
| SCHEMBL5179360 | 0.83 | RNPEP (0.48) | LMNARNPEPCA2CA1RAB9A | |
| Hydrochloric Acid SCHEMBL11456037 | 0.82 | LMNA (0.44) | LMNARNPEPCA2CA1RAB9A | |
| Iodide SCHEMBL11474184 | 0.82 | LMNA (0.44) | LMNARNPEPCA2CA1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089529-B1 | PRODUCTION OF STEREOISOMERS OF MONATIN VIA D-TRYPTOPHAN | CARGILL INC (US) | 2019-03-20 | — | — | EP | disclosed |
| US-9719079-B2 | Aldolases, nucleic acids encoding them and methods for making and using them | BASF ENZYMES LLC (US) | 2017-08-01 | — | — | US | disclosed |
| EP-3168299-A2 | POLYPEPTIDES AND BIOSYNTHETIC PATHWAYS FOR THE PRODUCTION OF STEREOISOMERS OF MONATIN AND THEIR PRECURSORS | Cargill, Incorporated (US) | 2017-05-17 | — | — | EP | disclosed |
| EP-3153580-A2 | ALDOLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM | BASF Enzymes LLC (US) | 2017-04-12 | — | — | EP | disclosed |
| US-9518280-B2 | Aldolases, nucleic acids encoding them and methods for making and using them | CARGILL, INCORPORATED (US) | 2016-12-13 | — | — | US | disclosed |
| EP-2385108-B1 | Aldolases, nucleic acids encoding them and methods for making and using them | BASF ENZYMES LLC (US) | 2016-11-23 | — | — | EP | disclosed |
| US-20160251643-A1 | Aldolases, Nucleic Acids Encoding Them and Methods for Making and Using Them | VERENIUM CORPORATION | 2016-09-01 | — | — | US | disclosed |
| EP-2354240-B1 | Polypeptides and biosynthetic pathways | CARGILL INC (US) | 2016-07-06 | — | — | EP | disclosed |
| EP-2361976-B1 | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors | CARGILL INC (US) | 2016-05-25 | — | — | EP | disclosed |
| US-9290755-B2 | Aldolases, nucleic acids encoding them and methods for making and using them | BASF ENZYMES LLC (US) | 2016-03-22 | — | — | US | disclosed |
| US-20050282260-A1 | Polypeptides and biosynthetic pathways for the production of monatin and its precursors | CARGILL, INCORPORATED | 2005-12-22 | — | — | US | disclosed |
| US-20050244937-A1 | Contacting a polypeptide with tryptophan or 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid to facilitate a conversion of tryptophan to indole-3-pyruvate, a conversion of 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid to 2-Hydroxy-2-(indol-3-ylmethyl)-4-aminoglutaric acid (monatin) | CARGILL, INC. | 2005-11-03 | — | — | US | disclosed |
| US-20050221455-A1 | Production of monatin and monatin precursors | CARGILL, INC. | 2005-10-06 | — | — | US | disclosed |
| US-20050170041-A1 | Chewing gum compositions comprising monatin and methods for making same | CARGILL, INC. | 2005-08-04 | — | — | US | disclosed |
| US-20050112260-A1 | Monatin tabletop sweetener compositions and methods of making same | CARGILL, INC. | 2005-05-26 | — | — | US | disclosed |
| US-20050106305-A1 | Beverage compositions comprising monatin and methods of making same | CARGILL, INC. | 2005-05-19 | — | — | US | disclosed |
| WO-2005020721-A1 | BEVERAGE COMPOSITIONS COMPRISING MONATIN AND METHODS OF MAKING SAME | CARGILL, INCORPORATED (US) | 2005-03-10 | — | — | WO | disclosed |
| WO-2005016022-A1 | CHEWING GUM COMPOSITIONS COMPRISING MONATIN AND METHODS OF MAKING SAME | CARGILL, INCORPORATED (US) | 2005-02-24 | — | — | WO | disclosed |
| WO-2005014839-A2 | MONATIN TABLETOP SWEETENER COMPOSITIONS AND METHODS OF MAKING SAME | CARGILL, INCORPORATED (US) | 2005-02-17 | — | — | WO | disclosed |
| US-20040063175-A1 | Polypeptides and biosynthetic pathways | CARGILL, INCORPORATED | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050244937-A1 | Contacting a polypeptide with tryptophan or 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid to facilitate a conversion of tryptophan to indole-3-pyruvate, a conversion of 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid to 2-Hydroxy-2-(indol-3-ylmethyl)-4-aminoglutaric acid (monatin) | AADAT, KYAT3, MON2 | LMNA 785/4885RNPEP 968/4885CA2 348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.