Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8572767 | 0.85 | GAA (0.45) | PLK1GAAKDM4EMAPTHPGD | |
| SCHEMBL7453899 | 0.80 | GAA (0.44) | PLK1GAAKDM4EMAPTHPGD | |
| SCHEMBL8572559 | 0.78 | GAA (0.45) | PLK1GAAKDM4EMAPTHPGD | |
| SCHEMBL8572523 | 0.77 | PLK1 (0.46) | PLK1PDK2CFTRGAAHTT | |
| SCHEMBL7454511 | 0.76 | GAA (0.45) | PLK1PDK2GAAHPGDHTT | |
| SCHEMBL8567754 | 0.71 | HTT (0.51) | PLK1GAAKDM4EMAPTHTT | |
| SCHEMBL15074688 | 0.70 | KAT6A (0.59) | PLK1PDK2GAAKDM4EMAPT | |
| SCHEMBL30147654 | 0.70 | KAT6A (0.59) | PLK1PDK2GAAKDM4EMAPT | |
| SCHEMBL8572444 | 0.70 | FGFR1 (0.39) | PLK1GAAKDM4EMAPTHPGD | |
| SCHEMBL7445914 | 0.70 | MYC (0.53) | PLK1PDK2GAAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | claimed |
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |