Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 8/20 | 0.43 |
| ▸ | TUBB | P07437 | 8/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 8/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 8/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 8/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 8/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 8/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 8/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 8/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 8/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 8/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 8/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8570517 | 0.81 | HTT (0.45) | HTTLMNAALDH1A1KDM4EMAPT | |
| SCHEMBL8573482 | 0.80 | HTT (0.47) | HTTLMNAALDH1A1KDM4EMAPT | |
| SCHEMBL8569636 | 0.78 | HTT (0.45) | HTTLMNAALDH1A1KDM4EMAPT | |
| SCHEMBL8572767 | 0.74 | GAA (0.45) | HTTLMNAALDH1A1KDM4EMAPT | |
| SCHEMBL8572559 | 0.72 | GAA (0.45) | HTTLMNAALDH1A1KDM4EMAPT | |
| SCHEMBL7445914 | 0.72 | MYC (0.53) | HTTLMNAALDH1A1KDM4EMAPT | |
| SCHEMBL7453899 | 0.71 | GAA (0.44) | HTTLMNAALDH1A1KDM4EMAPT | |
| SCHEMBL7855891 | 0.71 | FGFR1 (0.40) | HTTLMNAALDH1A1KDM4EMAPT | |
| SCHEMBL7445923 | 0.71 | L3MBTL1 (0.48) | LMNAALDH1A1KDM4EPLK1NPSR1 | |
| SCHEMBL8568182 | 0.71 | PLK1 (0.48) | HTTALDH1A1KDM4EMAPTPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |