Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | FABP4 | P15090 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | HNF4A | P41235 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 2/20 | 0.45 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17461871 | 0.87 | FABP4 (0.56) | MYCALDH1A1FABP4PDK2PLK1 | |
| SCHEMBL28085560 | 0.84 | HNF4A (0.51) | ALDH1A1FABP4PDK2HNF4AL3MBTL1 | |
| SCHEMBL22256436 | 0.82 | FGFR1 (0.57) | MYCALDH1A1FABP4PDK2HNF4A | |
| SCHEMBL7445923 | 0.81 | L3MBTL1 (0.48) | ALDH1A1HNF4AL3MBTL1PLK1BCAT2 | |
| SCHEMBL29434886 | 0.81 | HNF4A (0.66) | ALDH1A1PDK2HNF4AL3MBTL1PLK1 | |
| SCHEMBL22256427 | 0.81 | FGFR1 (0.56) | MYCALDH1A1FABP4PDK2HNF4A | |
| SCHEMBL15472559 | 0.80 | CHRNB2 (0.56) | ALDH1A1L3MBTL1PLK1BCAT2CHRNB2 | |
| SCHEMBL3223294 | 0.80 | CHRNB2 (0.65) | ALDH1A1L3MBTL1BCAT2CHRNB2CHRNB4 | |
| SCHEMBL3701691 | 0.80 | PLK1 (0.49) | ALDH1A1PDK2HNF4AL3MBTL1PLK1 | |
| SCHEMBL28628791 | 0.76 | PLAU (0.49) | MYCFABP4HNF4ABCAT2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921800-A4 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL MYERS SQUIBB CO (US) | 2000-12-06 | — | — | EP | claimed |
| EP-0921800-A1 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-06-16 | — | — | EP | claimed |
| WO-1997029748-A1 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-08-21 | — | — | WO | claimed |