Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5094162 | 0.87 | ALDH1A1 (0.60) | ALDH1A1TDP1MAPK8KMT2AGAA | |
| SCHEMBL5213184 | 0.85 | ALDH1A1 (1.00) | ALDH1A1TDP1MAPK8KMT2AGAA | |
| SCHEMBL4558530 | 0.84 | ALDH1A1 (0.68) | ALDH1A1TDP1MAPK8KMT2AGAA | |
| SCHEMBL4939060 | 0.84 | KMT2A (0.82) | ALDH1A1TDP1MAPK8KMT2AGAA | |
| SCHEMBL2488732 | 0.83 | — | — | |
| SCHEMBL20818012 | 0.83 | TDP1 (1.00) | ALDH1A1TDP1MAPK8KMT2AGAA | |
| SCHEMBL7310026 | 0.83 | MAPK8 (1.00) | ALDH1A1TDP1MAPK8GAA | |
| SCHEMBL13692388 | 0.83 | TDP1 (0.72) | ALDH1A1TDP1MAPK8KMT2AGAA | |
| SCHEMBL861902 | 0.82 | TDP1 (0.71) | ALDH1A1TDP1MAPK8KMT2AGAA | |
| SCHEMBL5216347 | 0.81 | ALDH1A1 (0.68) | ALDH1A1TDP1MAPK8KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |