Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | FNTA | P49354 | 3/20 | 0.45 |
| ▸ | FNTB | P49356 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7128049 | 0.86 | MAPT (0.71) | HDAC6MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9100585 | 0.74 | HDAC1 (0.51) | HDAC6HDAC1MAPTMEN1KMT2A | |
| SCHEMBL8568305 | 0.74 | HDAC1 (0.57) | HDAC6HDAC1MAPTMEN1KMT2A | |
| SCHEMBL13722157 | 0.72 | MAPT (0.66) | MAPTMEN1KMT2AALDH1A1KDM1A | |
| SCHEMBL4776138 | 0.72 | MAPT (0.57) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL5435395 | 0.72 | MEN1 (0.71) | MAPTMEN1KMT2AALDH1A1KDM1A | |
| SCHEMBL7280026 | 0.71 | NPSR1 (0.62) | MAPTMEN1KMT2AALDH1A1KDM1A | |
| SCHEMBL13722563 | 0.70 | MEN1 (0.73) | HDAC6MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL17356858 | 0.69 | MAPT (0.51) | MAPTMEN1KMT2AALDH1A1KDM1A | |
| SCHEMBL179882 | 0.68 | MEN1 (1.00) | HDAC6MAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861394-A | COMPOUNDS AS ANTIISCHEMIC AGENTS, TREATMENT OF STROKES, ANTIHEMORRHEGENIC AGENTS, ANTIDEPRESSANTS OR TREATMENT OF SICKKLE CELL ANEMIA | BAYER AKTIENGESELLSCHAFT (DE) | 1999-01-19 | — | — | US | disclosed |