Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | PTAFR | P25105 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | AKT1 | P31749 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | CDC25A | P30304 | 1/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28965396 | 0.81 | SMN1; SMN2 (0.73) | SMN1; SMN2ADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL9710185 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2ADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL18210636 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2ADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL17962981 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2ADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL19821626 | 0.78 | SMN1; SMN2 (0.69) | SMN1; SMN2ADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL7935832 | 0.78 | SMN1; SMN2 (0.69) | SMN1; SMN2ADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL245306 | 0.77 | SMN1; SMN2 (1.00) | SMN1; SMN2ADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL63754 | 0.77 | SMN1; SMN2 (1.00) | SMN1; SMN2ADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL272506 | 0.77 | SMN1; SMN2 (1.00) | SMN1; SMN2ADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL19821623 | 0.76 | SMN1; SMN2 (0.66) | SMN1; SMN2ADRA1DPTAFRHTR1DHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0770064-A4 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CARDIOVASCULAR, INFLAMMATORY AND IMMUNE DISORDERS | CYTOMED INC (US) | 1998-01-14 | — | — | EP | disclosed |
| EP-0770064-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CARDIOVASCULAR, INFLAMMATORY AND IMMUNE DISORDERS | CYTOMED, INC. (US) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996000212-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CARDIOVASCULAR, INFLAMMATORY AND IMMUNE DISORDERS | CYTOMED, INC. (US) | 1996-01-04 | — | — | WO | disclosed |
| WO-1993011136-A1 | NEW PYRROLIDINE DERIVATIVES | JIN RO LIMITED (KR) | 1993-06-10 | — | — | WO | disclosed |