Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8568355 | 1.00 | MTNR1A (0.50) | MTNR1ADRD2SMYD3SMN1; SMN2KDM4E | |
| SCHEMBL8568363 | 1.00 | MTNR1A (0.50) | MTNR1ADRD2SMYD3SMN1; SMN2KDM4E | |
| SCHEMBL1716130 | 0.77 | SMYD3 (0.52) | MTNR1ASMYD3GAAMTNR1BCA1 | |
| SCHEMBL30358033 | 0.77 | MTNR1A (0.53) | MTNR1ADRD2SMYD3KDM4EALDH1A1 | |
| SCHEMBL428189 | 0.77 | MTNR1A (0.53) | MTNR1ADRD2SMYD3KDM4EALDH1A1 | |
| SCHEMBL5849585 | 0.77 | MTNR1A (0.53) | MTNR1ADRD2SMYD3KDM4EALDH1A1 | |
| SCHEMBL10756153 | 0.76 | ATM (0.41) | MTNR1ADRD2SMYD3SMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL5849580 | 0.76 | MTNR1A (0.52) | MTNR1ADRD2SMYD3KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL5849581 | 0.76 | MTNR1A (0.52) | MTNR1ADRD2SMYD3KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL6531864 | 0.76 | MTNR1A (0.52) | MTNR1ADRD2SMYD3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |