Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10762542 | 0.90 | ATM (0.47) | ATMMTNR1ADRD2SMN1; SMN2KDM4E | |
| SCHEMBL10921783 | 0.86 | SMYD3 (0.40) | MTNR1ADRD2GAAHTR1AMTNR1B | |
| SCHEMBL10761532 | 0.78 | PDPK1 (0.36) | MTNR1AHTR1ASMYD3ACHE | |
| SCHEMBL10756147 | 0.77 | ATM (0.41) | ATMMTNR1ADRD2SMN1; SMN2KDM4E | |
| SCHEMBL10852417 | 0.77 | ATM (0.41) | ATMMTNR1ADRD2SMN1; SMN2KDM4E | |
| SCHEMBL10919334 | 0.77 | MAPT (0.43) | ATMMTNR1AGAAMTNR1BSMYD3 | |
| SCHEMBL10919336 | 0.77 | MAPT (0.43) | ATMMTNR1AGAAMTNR1BSMYD3 | |
| SCHEMBL8568359 | 0.76 | MTNR1A (0.50) | ATMMTNR1ADRD2SMN1; SMN2KDM4E | |
| SCHEMBL8568363 | 0.76 | MTNR1A (0.50) | ATMMTNR1ADRD2SMN1; SMN2KDM4E | |
| SCHEMBL8568355 | 0.76 | MTNR1A (0.50) | ATMMTNR1ADRD2SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4585588-A | ANTIDEPRESSANTS | BEECHAM GROUP P.L.C. (GB) | 1986-04-29 | — | — | US | claimed |
| US-4638066-A | ANTIDEPRESSANTS | BEECHAM GROUP P.L.C. (GB) | 1987-01-20 | — | — | US | disclosed |
| EP-0088575-B1 | PENTACYCLIC COMPOUNDS | BEECHAM GROUP PLC (GB) | 1986-12-30 | — | — | EP | disclosed |
| US-4585588-A | ANTIDEPRESSANTS | BEECHAM GROUP P.L.C. (GB) | 1986-04-29 | — | — | US | disclosed |
| US-4504480-A | DIAZABENZOCYCLOHEPTAFLUORENE DERIVATRIVES, ANTIDEPRESSANTS | BEECHAM GROUP P.L.C. (GB) | 1985-03-12 | — | — | US | disclosed |
| EP-0088575-A2 | Pentacyclic compounds | BEECHAM GROUP PLC (GB) | 1983-09-14 | — | — | EP | disclosed |