Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.43 |
| ▸ | WNT3A | P56704 | 4/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7849247 | 0.83 | NR4A2 (0.61) | LMNARAB9AALDH1A1HTTADAM17 | |
| SCHEMBL7845184 | 0.82 | NR4A2 (0.62) | LMNARAB9AALDH1A1HTTMAPT | |
| SCHEMBL7842860 | 0.81 | LMNA (0.54) | LMNARAB9AALDH1A1HTTADAM17 | |
| SCHEMBL5006024 | 0.80 | ADAM17 (0.47) | RAB9AADAM17CTNNB1WNT3APOLB | |
| SCHEMBL13475940 | 0.79 | CYP2A6 (0.45) | LMNARAB9AALDH1A1HTTADAM17 | |
| SCHEMBL3717752 | 0.75 | ADAM17 (0.68) | LMNARAB9AALDH1A1ADAM17MAPT | |
| SCHEMBL6772493 | 0.75 | NR4A1 (0.58) | NPSR1NR4A2F7F3 | |
| SCHEMBL3996872 | 0.73 | NR4A2 (0.67) | ALDH1A1KMT2AMEN1NR4A2KDM4E | |
| SCHEMBL10411714 | 0.73 | PARP1 (0.45) | ALDH1A1MAPTKMT2AMEN1NPSR1 | |
| SCHEMBL2592748 | 0.73 | HSD17B10 (0.47) | ALDH1A1MAPTKMT2AMEN1CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821685-A1 | INDOLE-3-CARBONYL AND INDOLE-3-SULFONYL DERIVATIVES AS PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1998-02-04 | — | — | EP | disclosed |