Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8574757 | 0.86 | GAA (0.48) | GAAHDAC6HTTHDAC2HDAC8 | |
| SCHEMBL26931633 | 0.81 | GAA (0.38) | GAAHDAC6HDAC1HTTKDM4C | |
| SCHEMBL1019798 | 0.80 | POLB (0.42) | GAAHDAC6HDAC1HTTKDM4C | |
| SCHEMBL2301708 | 0.79 | GAA (0.43) | GAAHDAC6HDAC1HTTHDAC2 | |
| SCHEMBL1018937 | 0.78 | MEN1 (0.42) | HDAC6HDAC1HTTCCNB2CDK1 | |
| SCHEMBL697516 | 0.78 | PKM (0.39) | HDAC6HDAC1HTTKDM4CHDAC2 | |
| SCHEMBL14454108 | 0.77 | GAA (0.53) | GAAHTTKDM4CHDAC4MAPT | |
| SCHEMBL8570975 | 0.77 | GAA (0.40) | GAAHDAC6HDAC1HTTKDM4C | |
| SCHEMBL3205636 | 0.77 | CA12 (0.44) | HDAC6HDAC1MAPK1NPC1RAB9A | |
| SCHEMBL13349285 | 0.77 | GAA (0.41) | GAAHDAC6HDAC2HDAC8NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | claimed |