Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8572286 | 0.81 | HDAC1 (0.44) | GAAPOLBHDAC1HDAC6TSHR | |
| SCHEMBL4438092 | 0.78 | MEN1 (0.43) | POLBHTTKDM4CMEN1KMT2A | |
| SCHEMBL8569020 | 0.77 | GAA (0.44) | GAAHTTKDM4CHDAC1HDAC6 | |
| SCHEMBL10700790 | 0.76 | GAA (0.65) | GAAHTTKDM4CTSHRMEN1 | |
| SCHEMBL17372335 | 0.76 | POLB (0.38) | POLBHTTKDM4CHDAC1HDAC6 | |
| SCHEMBL8569915 | 0.75 | CA1 (0.52) | GAAPOLBHDAC1HDAC6TSHR | |
| SCHEMBL1004213 | 0.75 | GAA (0.45) | GAAHTTHDAC1HDAC6KMT2A | |
| SCHEMBL4172084 | 0.74 | HTT (0.50) | GAAHTTKDM4CHDAC6TSHR | |
| SCHEMBL8574757 | 0.74 | GAA (0.48) | GAAHTTHDAC6TSHRMEN1 | |
| SCHEMBL1001989 | 0.74 | HDAC6 (0.44) | GAAHTTHDAC1HDAC6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | claimed |