Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 known ✓ | P25103 | 2/20 | 0.34 |
| ▸ | TACR2 | P21452 | 16/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8569245 | 0.80 | CCR5 (0.50) | TACR2TACR1CCR5 | |
| Hydrochloric Acid SCHEMBL8570000 | 0.75 | TACR2 (0.44) | TACR2TACR1 | |
| Hydrochloric Acid SCHEMBL8569995 | 0.75 | TACR2 (0.44) | TACR2TACR1 | |
| SCHEMBL8571640 | 0.74 | TACR2 (0.44) | TACR2TACR1 | |
| Hydrochloric Acid SCHEMBL8570007 | 0.74 | TACR1 (0.53) | TACR2TACR1CCR5 | |
| Hydrochloric Acid SCHEMBL8661721 | 0.74 | TACR1 (0.53) | TACR2TACR1CCR5 | |
| SCHEMBL8574717 | 0.74 | TACR2 (0.42) | TACR2TACR1 | |
| SCHEMBL8567378 | 0.74 | TACR2 (0.39) | TACR2TACR1 | |
| SCHEMBL8569234 | 0.73 | CCR5 (0.39) | TACR2TACR1CCR5 | |
| SCHEMBL8574144 | 0.73 | TACR2 (0.38) | TACR2TACR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998007722-A1 | QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONIST | PFIZER LIMITED (GB) | 1998-02-26 | — | — | WO | claimed |
| WO-1998007722-A1 | QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONIST | PFIZER LIMITED (GB) | 1998-02-26 | — | — | WO | disclosed |