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SCHEMBL8569335

SCHEMBL8569335

Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCc4ccccc4)c3Cl)cccn2c1Br

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ BDKRB2 P30411 14/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8563788 0.99 BDKRB2 (1.00) BDKRB2
SCHEMBL8566095 0.92 BDKRB2 (0.86) BDKRB2
Hydrochloric Acid SCHEMBL8565360 0.91 BDKRB2 (0.86) BDKRB2
SCHEMBL8562889 0.91 BDKRB2 (1.00) BDKRB2
SCHEMBL8569441 0.90 BDKRB2 (1.00) BDKRB2
SCHEMBL8567110 0.90 BDKRB2 (1.00) BDKRB2
Hydrochloric Acid SCHEMBL8566695 0.90 BDKRB2 (0.98) BDKRB2
SCHEMBL8564948 0.90 BDKRB2 (0.87) BDKRB2
Hydrochloric Acid SCHEMBL8569063 0.90 BDKRB2 (1.00) BDKRB2
Hydrochloric Acid SCHEMBL8561903 0.90 BDKRB2 (1.00) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 — — EP disclosed
US-5574042-A ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN FUJISAWA PHARMACEUTICAL CO., LTD (JP) 1996-11-12 — — US disclosed
EP-0596406-A1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 — — EP disclosed