Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 6/20 | 0.35 |
| ▸ | MMP2 | P08253 | 5/20 | 0.35 |
| ▸ | MMP8 | P22894 | 5/20 | 0.35 |
| ▸ | MMP13 | P45452 | 5/20 | 0.35 |
| ▸ | MMP12 | P39900 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566997 | 0.86 | ADAMTS4 (0.37) | ADAMTS4MMP9MMP2MMP8MMP13 | |
| SCHEMBL8569673 | 0.84 | PTAFR (0.38) | ADAMTS4MMP9MMP2MMP8MMP13 | |
| SCHEMBL8561481 | 0.80 | PTAFR (0.49) | ALDH1A1HPGDITGA4 | |
| SCHEMBL8571598 | 0.78 | GAA (0.41) | MMP9MMP13ALDH1A1 | |
| SCHEMBL8564422 | 0.78 | AGER (0.30) | — | |
| SCHEMBL8565372 | 0.77 | PTAFR (0.41) | ADAMTS4MMP2MMP13ALDH1A1ITGA4 | |
| SCHEMBL8562738 | 0.77 | PTAFR (0.36) | ALDH1A1HPGD | |
| SCHEMBL8569517 | 0.76 | PTAFR (0.35) | — | |
| SCHEMBL8570622 | 0.76 | PTAFR (0.35) | — | |
| SCHEMBL8563029 | 0.75 | PTAFR (0.41) | ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0605434-B1 | IMIDAZO (4,5-C) PYRIDINE DERIVATIVES AS PAF ANTAGONISTS | BRITISH BIOTECH PHARM (GB) | 1998-08-19 | — | — | EP | claimed |