Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569391 | 1.00 | ALDH1A1 (0.42) | ALDH1A1LMNACASRHTR1AMAPT | |
| SCHEMBL8569387 | 1.00 | ALDH1A1 (0.42) | ALDH1A1LMNACASRHTR1AMAPT | |
| SCHEMBL4566586 | 0.81 | CASR (0.44) | ALDH1A1CASRHTR1ANISCHHPGD | |
| SCHEMBL8571070 | 0.79 | HPGD (0.46) | ALDH1A1LMNACASRHTR1AMAPT | |
| SCHEMBL8569211 | 0.79 | CASR (0.44) | LMNACASRHTR1AMAPTNISCH | |
| SCHEMBL8571067 | 0.79 | HPGD (0.46) | ALDH1A1LMNACASRHTR1AMAPT | |
| SCHEMBL8571072 | 0.79 | HPGD (0.46) | ALDH1A1LMNACASRHTR1AMAPT | |
| SCHEMBL8569202 | 0.79 | CASR (0.44) | LMNACASRHTR1AMAPTNISCH | |
| SCHEMBL8562492 | 0.78 | CASR (0.47) | LMNACASRHTR1AMAPTNISCH | |
| SCHEMBL8562491 | 0.78 | CASR (0.47) | LMNACASRHTR1AMAPTNISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |