Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 8/20 | 0.75 |
| ▸ | HTR3B | O95264 | 8/20 | 0.75 |
| ▸ | HTR3A | P46098 | 8/20 | 0.75 |
| ▸ | HTR3D | Q70Z44 | 8/20 | 0.75 |
| ▸ | HTR3C | Q8WXA8 | 8/20 | 0.75 |
| ▸ | HTR1A | P08908 | 3/20 | 0.66 |
| ▸ | HTR2C | P28335 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | CASP7 | P55210 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569971 | 0.98 | HTR3E (0.73) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8564852 | 0.87 | HTR2C (0.63) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8568649 | 0.86 | HTR3E (0.69) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8567791 | 0.86 | HTR3E (0.74) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8571231 | 0.86 | HTR3E (0.69) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8572446 | 0.83 | HTR3E (0.65) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL22796403 | 0.82 | HTR3E (0.68) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL22796408 | 0.82 | HTR3E (0.64) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8566718 | 0.81 | HTR3E (0.72) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8567570 | 0.81 | HTR3E (0.67) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | disclosed |
| US-5599812-A | ANTISEROTONINE AGENTS | ADIR ET COMPAGNIE (FR) | 1997-02-04 | — | — | US | disclosed |
| EP-0623620-A1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR ET COMPAGNIE (FR) | 1994-11-09 | — | — | EP | disclosed |