Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.56 |
| ▸ | RAD52 | P43351 | 4/20 | 0.42 |
| ▸ | S100A4 | P26447 | 1/20 | 0.42 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | HTR3A | P46098 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7849116 | 0.81 | ALDH1A1 (0.51) | PDE10ARAD52S100A4PIK3CGHTR1D | |
| SCHEMBL5460421 | 0.81 | PDE10A (0.59) | PDE10ARAD52KCNN3PIK3CGHTR1D | |
| SCHEMBL312516 | 0.81 | PDE10A (0.64) | PDE10ARAD52PIK3CGKDM4EALDH1A1 | |
| SCHEMBL8569589 | 0.81 | PDE10A (0.51) | PDE10AKCNN3PIK3CGCYP2C19NPC1 | |
| SCHEMBL659433 | 0.80 | PDE10A (0.67) | PDE10AKCNN3PIK3CGKDM4EALDH1A1 | |
| SCHEMBL13304943 | 0.79 | PDE10A (0.53) | PDE10ARAD52KCNN3PIK3CGHTR1D | |
| SCHEMBL8574299 | 0.79 | PIK3CG (0.51) | PDE10AKCNN3PIK3CGKDM4EMEN1 | |
| SCHEMBL13778098 | 0.78 | PDE10A (0.56) | PDE10ARAD52KCNN3PIK3CGHTR1D | |
| SCHEMBL28449011 | 0.78 | CCNT1 (0.53) | PDE10APIK3CGDYRK1AKDM4EMEN1 | |
| SCHEMBL12953239 | 0.78 | PDE10A (0.51) | PDE10ARAD52PIK3CGHTR1DHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843951-A | Analgesic composition of pyrazolo(1,5-A) pyrimidines | OTSUKA PHARMACEUTICAL FACTORY INC. (JP) | 1998-12-01 | — | — | US | disclosed |
| EP-0795555-A1 | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1997-09-17 | — | — | EP | disclosed |