Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566783 | 0.69 | CD38 (0.43) | EGFRERBB2ERBB4 | |
| SCHEMBL6999466 | 0.69 | EGFR (0.47) | EGFRERBB2BRAF | |
| SCHEMBL8566778 | 0.69 | CD38 (0.43) | EGFRERBB2ERBB4 | |
| SCHEMBL4559872 | 0.68 | EGFR (0.80) | EGFRERBB2 | |
| SCHEMBL4350714 | 0.67 | GRM1 (0.62) | EGFRERBB2KDREPHB4ERBB4 | |
| SCHEMBL7888586 | 0.67 | EGFR (0.63) | EGFRERBB2KDRERBB4BRAF | |
| SCHEMBL8568476 | 0.67 | EGFR (0.47) | EGFRERBB2 | |
| SCHEMBL7888585 | 0.66 | EGFR (0.61) | EGFRERBB2ERBB4 | |
| SCHEMBL4461974 | 0.65 | ERBB2 (0.71) | EGFRERBB2BRAF | |
| SCHEMBL30399944 | 0.64 | EGFR (0.49) | EGFRERBB2KDREPHA2EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885226-A1 | 4-AMINO PYRIMIDINE DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032881-A1 | 4-AMINO PYRIMIDINE DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |