SCHEMBL8570351

SCHEMBL8570351

O=C(Cl)c1cccc(Oc2cccc(C(F)(F)F)c2)n1

nearest known ligand 0.73

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.73
L3MBTL1 Q9Y468 3/20 0.48
ALDH1A1 P00352 3/20 0.48
POLB P06746 1/20 0.48
NTRK1 P04629 1/20 0.47
KDM4E B2RXH2 5/20 0.47
GAA P10253 3/20 0.46
RAB9A P51151 1/20 0.44
MAPK1 P28482 2/20 0.43
NPSR1 Q6W5P4 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
RECQL P46063 1/20 0.43
LRRK2 Q5S007 1/20 0.43
HSD17B14 Q9BPX1 1/20 0.43
ADORA2A P29274 1/20 0.43
PPARG P37231 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7110619 0.88 MAPT (0.74) MAPTL3MBTL1ALDH1A1POLBNTRK1
SCHEMBL8569584 0.86 MAPT (0.73) MAPTL3MBTL1ALDH1A1POLBNTRK1
SCHEMBL8725895 0.86 NTRK1 (0.58) MAPTL3MBTL1ALDH1A1POLBNTRK1
SCHEMBL3841693 0.85 MAPT (0.75) MAPTL3MBTL1ALDH1A1POLBNTRK1
SCHEMBL7528425 0.84 MAPT (1.00) MAPTL3MBTL1ALDH1A1POLBNTRK1
SCHEMBL7953536 0.84 MAPT (0.69) MAPTL3MBTL1ALDH1A1NTRK1KDM4E
SCHEMBL8065139 0.83 MAPT (0.72) MAPTL3MBTL1ALDH1A1POLBNTRK1
SCHEMBL7612444 0.83 MAPT (0.67) MAPTL3MBTL1ALDH1A1POLBNTRK1
SCHEMBL7965150 0.83 MAPT (0.67) MAPTL3MBTL1ALDH1A1NTRK1KDM4E
SCHEMBL8773158 0.82 MAPT (0.65) MAPTL3MBTL1ALDH1A1POLBNTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5750470-A Herbicidal 2,6-disubstituted pyridine compounds and compositions NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1998-05-12 US disclosed