Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5558972 | 0.86 | HPGD (0.60) | MAPK1SMN1; SMN2RECQLHPGDALDH1A1 | |
| SCHEMBL8570808 | 0.84 | RECQL (0.55) | MAPK1SMN1; SMN2RECQLALDH1A1MAPT | |
| SCHEMBL2149188 | 0.77 | ALDH1A1 (0.45) | SMN1; SMN2HPGDALDH1A1MAPTL3MBTL1 | |
| SCHEMBL5717757 | 0.77 | MAPK1 (1.00) | MAPK1SMN1; SMN2RECQLHPGDALDH1A1 | |
| SCHEMBL14199038 | 0.74 | POLB (0.41) | MAPK1RECQLHPGDALDH1A1L3MBTL1 | |
| SCHEMBL15157087 | 0.72 | KMT2A (0.45) | RECQLHPGDALDH1A1L3MBTL1KMT2A | |
| SCHEMBL3354467 | 0.72 | POLB (0.41) | MAPK1SMN1; SMN2RECQLHPGDALDH1A1 | |
| SCHEMBL9715954 | 0.70 | POLB (0.39) | MAPK1RECQLHPGDALDH1A1L3MBTL1 | |
| SCHEMBL5282646 | 0.70 | KMT2A (0.42) | RECQLHPGDALDH1A1MAPTL3MBTL1 | |
| SCHEMBL5282527 | 0.69 | KMT2A (0.44) | MAPK1ALDH1A1MAPTL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |