SCHEMBL8570511

SCHEMBL8570511

FC(F)(F)C(F)(F)CCCCCCO[Si](c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
DUT P33316 1/20 0.40
HDAC1 Q13547 4/20 0.33
HDAC2 Q92769 4/20 0.33
KCNA3 P22001 1/20 0.31
HDAC3 O15379 2/20 0.30
HDAC4 P56524 2/20 0.30
HDAC7 Q8WUI4 2/20 0.30
HDAC10 Q969S8 2/20 0.30
HDAC11 Q96DB2 2/20 0.30
HDAC8 Q9BY41 2/20 0.30
HDAC6 Q9UBN7 2/20 0.30
HDAC9 Q9UKV0 2/20 0.30
HDAC5 Q9UQL6 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8570256 0.89 DUT (0.38) DUTHDAC1HDAC2
SCHEMBL8573365 0.80 DUT (0.42) DUTHDAC1HDAC2KCNA3HDAC3
SCHEMBL8571562 0.77 DUT (0.40) DUTKCNA3
SCHEMBL8572762 0.76 DUT (0.40) DUT
SCHEMBL8568793 0.75 DUT (0.35) DUT
SCHEMBL8571424 0.74 DUT (0.35) DUT
SCHEMBL8567403 0.74 DUT (0.35) DUT
SCHEMBL8572494 0.74 DUT (0.41) DUT
SCHEMBL8714366 0.74 CYSLTR2 (0.32)
SCHEMBL8717884 0.72 KIF11 (0.49) DUT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5744678-A NICKEL COMPOUND, ORGANOPHOSPHORUS COMPOUND, ORGANOALUMINUM COMPOUND, CARBON-HALOGEN COMPOUNDS; CATALYST SELECTIVITY NIPPON OIL CO., LTD. (JP) 1998-04-28 US disclosed
US-5728641-A Catalyst component for the polymerization of olefins NIPPON OIL COMPANY, LIMITED (JP) 1998-03-17 US disclosed
EP-0758563-A1 OLEFIN OLIGOMERIZATION CATALYST AND PROCESS FOR THE PREPARATION OF OLEFIN OLIGOMER USING IT NIPPON OIL COMPANY, LTD. (JP) 1997-02-19 EP disclosed
EP-0587440-A2 Catalyst component for the polymerisation of olefins and process for preparing olefin polymers using same NIPPON OIL COMPANY, LIMITED (JP) 1994-03-16 EP disclosed