Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.42 |
| ▸ | HAT1 | O14929 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31147988 | 0.81 | NR4A2 (0.63) | NR4A2HAT1EP300 | |
| SCHEMBL27839464 | 0.78 | NR4A2 (0.46) | NR4A2HAT1EP300 | |
| SCHEMBL27967224 | 0.78 | NR4A2 (0.57) | TSHRALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL29800593 | 0.77 | NR4A2 (0.54) | TSHRALDH1A1KDM4EL3MBTL1MEN1 | |
| SCHEMBL22864631 | 0.77 | NR4A2 (0.54) | TSHRALDH1A1KDM4EL3MBTL1MEN1 | |
| SCHEMBL27961666 | 0.77 | TSHR (0.66) | TSHRALDH1A1KDM4ETDP1L3MBTL1 | |
| SCHEMBL7846022 | 0.77 | KDM4E (0.55) | ALDH1A1KDM4EMEN1KMT2AHAT1 | |
| SCHEMBL18975022 | 0.75 | TSHR (0.47) | TSHRALDH1A1KDM4ETDP1L3MBTL1 | |
| SCHEMBL7494290 | 0.75 | MAPT (0.57) | LMNAMEN1KMT2AHAT1EP300 | |
| SCHEMBL6325476 | 0.74 | NR4A2 (0.47) | GSK3BNR4A2HAT1EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821685-A1 | INDOLE-3-CARBONYL AND INDOLE-3-SULFONYL DERIVATIVES AS PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1998-02-04 | — | — | EP | disclosed |