Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.54 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22864631 | 1.00 | NR4A2 (0.54) | NR4A2GABRA1GABRB2TSHRGABRB1 | |
| SCHEMBL4742551 | 0.91 | GABRA1 (0.63) | GABRA1GABRB2GABRB1GABRA3ALDH1A1 | |
| SCHEMBL30175047 | 0.89 | ALDH1A1 (0.61) | NR4A2GABRA1GABRB2TSHRGABRB1 | |
| SCHEMBL5313637 | 0.89 | ALDH1A1 (0.61) | NR4A2GABRA1GABRB2TSHRGABRB1 | |
| SCHEMBL1557626 | 0.86 | ALDH1A1 (0.47) | NR4A2GABRA1GABRB2ALDH1A1MEN1 | |
| SCHEMBL5245797 | 0.84 | CA12 (0.56) | NR4A2GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL6421158 | 0.84 | IMPDH2 (0.63) | NR4A2GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL4235843 | 0.84 | NR4A2 (0.70) | NR4A2 | |
| SCHEMBL6490095 | 0.83 | GABRA1 (0.70) | NR4A2GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL846416 | 0.82 | GABRA1 (0.74) | GABRA1GABRB2GABRB1GABRA3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114555585-A | HPK1 inhibitors and uses thereof | 上海齐鲁锐格医药研发有限公司 | 2022-05-27 | — | — | CN | disclosed |