Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.60 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.60 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7662083 | 0.89 | CYP4A11 (0.48) | CYP4F2CYP4A11CYP4Z1EPHX2LMNA | |
| SCHEMBL7766764 | 0.86 | CYP4F2 (0.70) | CYP4F2CYP4A11CYP4Z1EPHX2LMNA | |
| SCHEMBL31635260 | 0.85 | LMNA (0.56) | CYP4F2CYP4A11CYP4Z1LMNAMAPT | |
| SCHEMBL7582610 | 0.85 | ADRB2 (0.48) | CYP4F2CYP4A11LMNAMAPTL3MBTL1 | |
| SCHEMBL16838984 | 0.82 | SMN1; SMN2 (0.52) | CYP4F2CYP4A11LMNAMAPTL3MBTL1 | |
| SCHEMBL68902 | 0.82 | CYP4F2 (0.85) | CYP4F2CYP4A11CYP4Z1EPHX2LMNA | |
| SCHEMBL3790673 | 0.81 | NR1H4 (0.51) | EPHX2LMNAL3MBTL1NPSR1CA12 | |
| SCHEMBL13891334 | 0.81 | PLK1 (0.51) | CYP4F2CYP4A11MAPTL3MBTL1GAA | |
| SCHEMBL18608207 | 0.81 | CA1 (0.63) | LMNAMAPTTDP1MAPK1NPSR1 | |
| SCHEMBL879130 | 0.81 | CYP4F2 (0.77) | CYP4F2CYP4A11CYP4Z1EPHX2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0530579-B1 | Condensed pyrimidine derivatives antitumor agents | EISAI CO LTD (JP) | 1998-11-11 | — | — | EP | disclosed |
| US-5688800-A | ANTITUMOR AGENTS | EISAI CO., LTD. (JP) | 1997-11-18 | — | — | US | disclosed |
| US-5554615-A | ANTITUMOR | EISAI CO., LTD. (JP) | 1996-09-10 | — | — | US | disclosed |
| EP-0530579-A1 | Condensed pyrimidine derivatives antitumor agents | Eisai Co., Ltd. (JP) | 1993-03-10 | — | — | EP | disclosed |
| US-4742052-A | Antibacterial β-lactam compounds | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1988-05-03 | — | — | US | disclosed |
| EP-0070204-A2 | Carboxylic beta-lactam compounds and the preparation thereof | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1983-01-19 | — | — | EP | disclosed |